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Insulin Aspart+insulin Degludec

About Insulin Aspart+insulin Degludec

Insulin Aspart+insulin Degludec used for the treatment of both type 1 and type 2 diabetes mellitus. It maintains blood sugar levels in adults and children. In Type 1 Diabetes Mellitus, the body does not produce enough insulin to regulate blood sugar levels. In type 2 diabetes mellitus, either the body stops producing enough insulin (a hormone that helps lower blood sugar levels) or there is resistance to the action of insulin. As a result, insulin is produced in large quantities, but it is unable to function properly on the body's organs.

Insulin Aspart+insulin Degludec is a combination medicine that works by promoting the recovery of sugar in muscle and fat cells and suppressing sugar production in the liver. Together, Insulin Aspart+insulin Degludec confirms rapid and stable sugar control.

Not everyone who is taking Insulin Aspart+insulin Degludec will get these side effects. You may experience rash, injection site allergic reaction, weight gain, edema (tissue swelling or fluid overload), skin thickening at the injection site, low blood glucose levels, and itching. Most of these side effects of Insulin Aspart+insulin Degludec do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Insulin Aspart+insulin Degludec should be taken before food or advised by your doctor. It should be administered subcutaneously (in the upper thigh, abdomen, upper arm, or buttocks) only. Your doctor will explain how to inject the medicine by your own. However, if it is difficult to inject the medicine, ask a healthcare professional to administer it. Along with Insulin Aspart+insulin Degludec, you should take a healthy diet, do regular exercise, and maintain weight as advised by your doctor. 

Inform your doctor if you are allergic to Insulin Aspart+insulin Degludec. Do not take Insulin Aspart+insulin Degludec if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription or recreational drugs. Try not to stop receiving Insulin Aspart+insulin Degludec of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Insulin Aspart+insulin Degludec is a cold chain medicine, and so it must be stored in the refrigerator between 2-8 degrees Celsius, or else its efficiency might get lost. Do not store in the freezer or the fridge.

Uses of Insulin Aspart+insulin Degludec

Insulin Aspart+insulin Degludec is used in the treatment of Diabetes (type 1 diabetes mellitus and type 2 diabetes mellitus). The detailed uses of Insulin Aspart+insulin Degludec are as follows:
• Diabetes Management: Insulin Aspart+insulin Degludec is primarily used to regulate blood glucose levels in individuals with diabetes mellitus, helping to keep them within a healthy range.
• Postprandial Blood Sugar Control: Insulin Aspart+insulin Degludec effectively manages postprandial (after meal) blood sugar spikes through its combination of intermediate and short-acting insulin.
• Type 1 and Type 2 Diabetes Treatment: Insulin Aspart+insulin Degludec is prescribed for patients with Type 1 and Type 2 diabetes who are unable to achieve adequate glycemic control with oral hypoglycemic agents alone.

Medicinal Benefits

  • Insulin Aspart+insulin Degludec is an antidiabetic medicine primarily used for the treatment of both type 1 and type 2 diabetes mellitus.
  • Insulin Aspart+insulin Degludec works by ensuring rapid and consistent sugar control. It typically begins working after 60 minutes and is a long-acting insulin preparation (lasts for more than 24 hours). Together, they confirm rapid and stable sugar control by facilitating the reuptake of sugar in fat and muscle cells and suppressing the production of sugar in the liver.
  • It prevents the risk of having severe complications of diabetes. It stimulates the recovery of sugar in muscle and fat cells, thereby suppressing sugar production in the liver.
  • Insulin Aspart+insulin Degludec helps improve glycaemic control, which in turn decreases the risk of complications of diabetes, such as damage to the retina (retinopathy), damage to the kidneys (nephropathy), impairment of nerve cells (neuropathy), delayed wound healing, diabetic foot ulcers, and others.
  • Insulin Aspart+insulin Degludec can also be safely prescribed to the diabetic mother during pregnancy and lactation.

Directions for Use

• Follow your doctor's instructions regarding the dosage and duration of treatment. • Insulin Aspart+insulin Degludec should be administered subcutaneously (in the upper thigh, abdomen, upper arm, or buttocks). • It should never be administered intravenously or in the vein. • If you are not well trained to self-administer it, ask a healthcare professional to administer it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Insulin Aspart+insulin Degludec

  • Rashes
  • Injection site allergic reaction
  • Weight gain
  • Swelling
  • Skin thickening at the injection site
  • Low blood glucose levels
  • Itching

Drug Warnings

Inform your doctor if you are allergic to Insulin Aspart+insulin Degludec. Do not take Insulin Aspart+insulin Degludec if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription or recreational drugs. Try not to stop receiving Insulin Aspart+insulin Degludec of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Insulin Aspart+insulin Degludec may decrease the level of potassium, leading to a state of hypokalaemia that, if left untreated, may lead to respiratory paralysis, irregular heartbeat rhythm, coma, and even death.

Insulin Aspart+insulin Degludec is for subcutaneous (under the skin) use only. If you are switching to a different insulin brand or using a different method of injection, it should be done under strict medical supervision. Cases of heart failure have been reported when pioglitazone was used with insulin, especially in patients at high risk of cardiac heart failure. The first symptoms of hyperglycemia (high blood sugar levels) may include excessive thirst, dry mouth, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite, and an acetone odour in the breath. You should closely monitor these symptoms.

It is advisable not to consume alcohol, as it may either increase or decrease your blood glucose level. Care should be taken while travelling across more than two time zones. Your doctor may adjust your insulin schedule. Insulin Aspart+insulin Degludec is a cold chain medicine, and therefore it must be stored in the refrigerator at a temperature between 2-8 degrees Celsius, or else its efficiency may be compromised. Do not store in the freezer or the fridge.

Keep the medicine out of reach of children. Please do not inject more than the recommended dose of medicine, as it can cause undesirable effects. It is always important to check the expiry date of the medicine. Discard the medicine if it reaches the expiry date. Insulin Aspart+insulin Degludec should not be administered intravenously (into the vein).

Drug Interactions

Drug-Drug Interaction: Insulin Aspart+insulin Degludec may have an interaction with pain killers (aspirin), antibiotics (isoniazid, pentamidine, ciprofloxacin), blood sugar enhancing pills (glucagon), male hormone testosterone analogue (danazol), antidiabetics (metformin), lipid-lowering pills (reserpine, niacin), blood pressure-lowering medicines (atenolol, acebutolol, metoprolol), thyroid hormones (levothyroxine), an antidepressant (fluoxetine, lithium), female sex hormones (progestogen, estrogen).

Drug-Food Interaction: Insulin Aspart+insulin Degludec may interact with an ayurvedic, homeopathy, Unani, herbal supplements, or OTC items. Tell your doctor if you are using these products. Try to avoid alcoholic beverages with Insulin Aspart+insulin Degludec as it may increase or decrease your blood sugar level.

Drug-Disease Interaction: Insulin Aspart+insulin Degludec should not be given to patients with kidney disease, liver disease, low blood sugar/glucose level (hypoglycemia), and low potassium level (hypokalaemia).

Drug-Drug Interactions Checker List:

  • ASPIRIN
  • ISONIAZID
  • PENTAMIDINE
  • CIPROFLOXACIN
  • GLUCAGON
  • DANAZOL
  • METFORMIN
  • RESERPINE
  • NIACIN
  • ATENOLOL
  • ACEBUTOLOL
  • METOPROLOL
  • LEVOTHYROXINE
  • FLUOXETINE
  • LITHIUM
  • PROGESTERONE
  • ESTROGEN
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      You are recommended not to consume alcohol along with Insulin Aspart+insulin Degludec to avoid unpleasant side-effects. Alcohol may either decrease or increase the blood sugar level which can be fatal.

    • Safety Warning

      Pregnancy

      safe if prescribed

      Insulin Aspart+insulin Degludec can be used during pregnancy. Your insulin dose may need to be changed during pregnancy and after delivery.

    • Safety Warning

      Breast Feeding

      safe if prescribed

      Insulin Aspart+insulin Degludec can be given safely to nursing mothers but only under the supervision of a doctor.

    • Safety Warning

      Driving

      unsafe

      Drive with caution, Insulin Aspart+insulin Degludec usually causes drowsiness and affects driving ability. Your ability to concentrate and react may be reduced if you have hypoglycemia (low blood sugar).

    • Safety Warning

      Liver

      caution

      Insulin Aspart+insulin Degludec to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Kidney

      caution

      Insulin Aspart+insulin Degludec to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Children

      consult your doctor

      Insulin Aspart+insulin Degludec can be given in children only if recommended by the physician.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Exercise may lower your body’s need for insulin during and for some time after the physical activity.
    • Exercise may also speed up the insulin dose effect, especially if the exercise involves the injection site area (for example, the leg should not be used for injection just before running).
    • Discuss with your doctor how you should adjust your insulin regimen to accommodate exercise.
    • Avoid eating sugary food and prefer food cooked food low in calories.
    • When travelling across more than 2 time zones, you should talk to your doctor about your insulin schedule adjustments.

    Special Advise

    • Your doctor may recommend regular potassium level checks, as prolonged administration can cause a life-threatening condition of hypokalemia (low potassium levels).
    • Store Insulin Aspart+insulin Degludec at a temperature between 2-8 degrees Celsius only. Do not store Insulin Aspart+insulin Degludec in the freezer. 

    Patients Concern

    Disease/Condition Glossary

    Type 1 diabetes mellitus: In type 1 diabetes mellitus, our body does not make insulin (the hormone which helps to decrease sugar levels in the blood) to control blood sugar levels.

    Type 2 diabetes mellitus: In type 2 diabetes mellitus, either the body stops producing enough insulin or there is resistance to the action of insulin. As a result, insulin is produced in sufficient amounts but is unable to act on the tissues of the organs.

    FAQs

    Insulin Aspart+insulin Degludec is used for the treatment of both type 1 and type 2 diabetes mellitus. It maintains blood sugar levels in adults and children.

    Insulin Aspart+insulin Degludec can be given to treat both the condition of type 1 and type 2 diabetes mellitus. However, your doctor will decide whether Insulin Aspart+insulin Degludec can be given to you or not depending on your present condition. Insulin Aspart+insulin Degludec should be avoided in patients who are allergic to Insulin Aspart+insulin Degludec or other forms of insulin, patients with kidney disease, liver disease, low blood sugar/glucose level (hypoglycemia), and low potassium level (hypokalaemia).

    Cold sweat, cool pale skin, headache; rapid heartbeat, feeling sick, feeling very hungry, temporary vision changes, drowsiness, unusual tiredness and weakness, nervousness or tremor, feeling anxious, feeling confused, difficulty in concentrating are some of the common signs of the low blood sugar level in an individual.

    If you experience low blood sugar, eat glucose tablets or another high sugar snack (e.g. sweets, biscuits, fruit juice). Measure your blood sugar if possible and rest. Always carry glucose tablets or high sugar snacks with you. You should give a call to any of your family members if you are feeling dizziness or drowsiness. Consult a doctor immediately.

    It is advised to tell all the medicines that you are using to your doctor like pioglitazone or rosiglitazone as taking other diabetes medicines may increase the risk of serious heart problems.

    Local allergic reactions (pain, redness, hives, inflammation, bruising, swelling, and itching) at the injection site may occur. These usually disappear after a few weeks of taking your insulin. If they do not disappear, or if they spread throughout your body, talk to your doctor immediately.

    Insulin Aspart+insulin Degludec does not help in weight loss. It is used to control blood sugar levels in people with diabetes.

    Insulin Aspart+insulin Degludec may cause side effects such as rash, injection site allergic reaction, weight gain, oedema (tissue swelling or fluid overload), lipodystrophy (skin thickening or pits at the injection site), hypoglycaemia (low blood glucose level), and itching. Most of these side effects of Insulin Aspart+insulin Degludec do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

    Insulin Aspart+insulin Degludec is not typically used for weight loss. In fact, insulin therapy can sometimes lead to weight gain due to increased insulin levels and improved glucose uptake in the body. If you have any concerns regarding weight loss, consult your doctor.

    Insulin Aspart+insulin Degludec is a combination of two insulins. One (Insulin Aspart) works quickly to lower blood sugar after meals, and the other (Insulin Degludec) works slowly to control blood sugar throughout the day. Together, they help your body use sugar properly and reduce sugar production in the liver. This leads to better blood sugar control.

    Insulin Aspart+insulin Degludec is used to treat adults with type 1 or type 2 diabetes, helping to control blood sugar levels in addition to diet and exercise. However, it should only be used under the guidance of a physician, who will assess your overall health, medical history, and age before prescribing it.

    Use Insulin Aspart+insulin Degludec precisely as prescribed. Inject it once daily, at the same time, with or without meals. Remember to rotate injection sites to avoid any skin issues. Also, monitor your blood sugar levels regularly and follow your doctor's instructions for best results.

    No, do not mix Insulin Aspart+insulin Degludec with any other insulins. Please consult your doctor if you have any concerns.

    Store Insulin Aspart+insulin Degludec between 36° to 46°F (2° and 8°C). Keep it away from the freezer and the refrigerator's cooling element. Never freeze it, and don't use it if it’s frozen. Also, keep it out of reach of children.

    Insulin Aspart+insulin Degludec is safe to use during pregnancy and breastfeeding if prescribed by the doctor.

    If you take too much of Insulin Aspart+insulin Degludec, it can cause a severe overdose and low blood sugar. Symptoms include confusion, dizziness, and shaking. If you think you've taken too much, get medical help immediately. Always follow the prescribed dosage to stay safe.

    It is not known if Insulin Aspart+insulin Degludec is safe and effective in children under 18 years of age. Please consult the doctor if you have any concerns.

    It is essential to monitor your blood sugar levels while using Insulin Aspart+insulin Degludec. Regular blood sugar monitoring helps you understand how your body responds to the medication, allows you to make informed decisions about your diet and activity, and helps your healthcare provider adjust your treatment plan if needed.

    If you experience an allergic reaction to Insulin Aspart+insulin Degludec, seek medical attention immediately. Symptoms of an allergic reaction may include hives, itching, swelling, difficulty breathing, and rapid heartbeat. Call emergency services or go to the nearest hospital if you experience severe symptoms. Inform your healthcare provider about the allergic reaction, as they may need to adjust your treatment plan.

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    Insulin Aspart+insulin Degludec

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